Figure 4.

(a) Visual predictive check for tumor kinetics; (b) visual predictive check for survival; (c) simulated individual tumor kinetic profiles including dropout from one representative simulated trial. (a) Circles represent the observed individual data; solid line represents the observed median; dashed lines represent the observed 5^th and 95^th percentiles; shaded areas show 95% confidence intervals of model‐predicted median, 5^th and 95^th percentiles based on 500 visual predictive check runs incorporating between‐subject variability and residual variability. (b) Solid line and shaded area represent observed and 95% confidence interval of model‐predicted Kaplan–Meier curve for overall survival, respectively.