Table 5.
Patient disposition
| Disposition – n (%) | Cohort 1 (n = 13) | Cohort 2 (n = 18) | Cohort 3 (n = 18) | Cohort 4 (n = 43) | Overall (N = 92) |
|---|---|---|---|---|---|
| On treatment | 1 (8) | 0 (0) | 0 (0) | 6 (14) | 7 (8) |
| Discontinued treatment | 12 (92) | 18 (100) | 18 (100) | 37 (86) | 85 (92) |
| Progressive disease | 6 (46) | 11 (61) | 12 (67) | 26 (60) | 55 (60) |
| Investigator discretion | 3 (23) | 6 (33) | 2 (11) | 1 (2) | 12 (13) |
| Adverse event | 1 (8) | 0 (0) | 3 (17) | 5 (12) | 9 (10) |
| Othera | 2 (15) | 1 (6) | 1 (6) | 5 (12) | 9 (10) |
a
Includes patient withdrawal, noncompliance, and patient required prohibited concomitant medication.