Table 1.
TNFa & NFkB related transcripts are highly altered Pathway analysis results of microarray data processed through WikiPathways analysis.
| Pathway | Total number of changes | Up in MUTFUS | Down in MUTFUS | Significance (z score) |
|---|---|---|---|---|
| Protein‐protein interactions in the podocyte (XPodNet) | 209 | 92 | 117 | 7.77 |
| Pluripotency associated networks (PluriNetWork) | 80 | 43 | 37 | 4.79 |
| Focal Adhesion Kinase‐PI3K‐AKT‐mTOR signaling | 68 | 27 | 41 | 1.04 |
| mRNA processing | 60 | 32 | 28 | 2.31 |
| TNF‐alpha and NF‐KB signaling | 48 | 23 | 25 | 2.5 |
| MAPK | 43 | 24 | 19 | 2.12 |
| EGFR1 | 42 | 21 | 21 | 1.56 |
| Adipogenesis | 37 | 22 | 15 | 2.59 |
| Myometrial relaxation and contraction | 37 | 19 | 18 | 1.36 |
| Purine metabolism | 37 | 23 | 14 | 0.9 |
| Insulin signaling | 36 | 16 | 20 | 1.03 |
| TGF‐beta receptor signaling | 36 | 18 | 18 | 1.41 |
| Chemokine signaling | 35 | 19 | 16 | 0.2 |
| Androgen receptor signaling | 30 | 13 | 17 | 1.93 |
| Wnt signaling | 29 | 14 | 15 | 2.57 |
| Regulation of actin cytoskeleton | 28 | 12 | 16 | 0.18 |
| T cell receptor signaling | 28 | 16 | 12 | 0.6 |
| B cell receptor signaling | 26 | 13 | 13 | 0.04 |
| Non‐odorant GPCRs | 26 | 13 | 13 | 3.22 |
| Il‐3 signaling | 25 | 11 | 14 | 1.33 |
Shown are the top 20 most altered pathways as determined by the combined number of significantly altered genes within each pathway along with the number of changes and the significance score ranking. In bold is the TNF‐alpha and NF‐KB signaling pathway which was chosen as a candidate pathway for further analysis based on previous evidence of role of the TNF‐alpha and NF‐KB pathways in regulating cytokines and inflammatory cell‐to‐cell signals.