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. 2018 Jan 4;233(6):5014–5022. doi: 10.1002/jcp.26353

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© 2017 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Circulating tumor cells (CTCs) in patients with ampullary cancer and healthy controls. Cells consistent with CTC staining patterns in patients with ampullary cancer were significantly higher than those in healthy controls (p < 0.001) (a). Receiver operating characteristic curve for CTC identification by combination staining with CD45, 4′,6‐diamidino‐2‐phenylindole (DAPI), and fluorescence in situ hybridization‐CEP8 in ampullary cancers. The sensitivity of CTCs for the diagnosis of ampullary cancer was 69.4% and the specificity was 95.8% when using a cutoff value of 2 cells/3.2 ml. The area under the curve is 0.854 (95% confidence interval: 0.777–0.931, p < 0.001)