Table 1.

Mean accuracy estimates of cerebroplacental ratio (CPR) and middle cerebral artery (MCA) Doppler for different adverse outcomes, based on fixed thresholds investigated in at least three studies

Index test; threshold	Outcome	Studies (n)	Patients (n)	Sensitivity			Specificity
				Estimated mean	95% CI	95% predict int	Estimated mean	95% CI	95% predict int
CPR‐PI; 1.0–1.1	Perinatal death	10	3571	0.93	0.71–0.99	0.15–0.99	0.74	0.62–0.84	0.32–0.95
	5‐min Apgar score < 7	9	1370	0.61	0.53–0.68	0.47–0.73	0.76	0.69–0.82	0.55–0.89
	ED for fetal distress	8	2559	0.58	0.39–0.74	0.15–0.92	0.89	0.79–0.94	0.52–0.98
	NICU admission	12	2603	0.55	0.44–0.65	0.24–0.83	0.85	0.79–0.90	0.60–0.95
	Composite adverse outcome	13	2591	0.59	0.44–0.73	0.15–0.92	0.91	0.82–0.96	0.39–0.99
CPR‐RI; 1.0–1.1	Perinatal death	5	450	0.84	0.63–0.94	0.45–0.97	0.67	0.45–0.84	0.19–0.95
	5‐min Apgar score < 7	8	1782	0.75	0.42–0.93	0.06–0.99	0.84	0.63–0.94	0.16–0.99
	NICU admission	4	299	0.66	0.46–0.82	0.30–0.76	0.63	0.49–0.76	0.36–0.84
	Composite adverse outcome	4	409	0.80	0.69–0.89	0.59–0.93	0.85	0.66–0.94	0.40–0.98
MCA‐PI; < 2 SD16	Perinatal death	3	92	0.48	0.28–0.68	0.27–0.69	0.72	0.53–0.85	0.40–0.91
	5‐min Apgar score < 7	3	125	0.56	0.35–0.75	0.32–0.77	0.65	0.45–0.80	0.31–0.88
	ED for fetal distress	3	167	0.52	0.36–0.68	0.28–0.75	0.84	0.51–0.97	0.25–0.99
	NICU admission	5	385	0.45	0.33–0.57	0.23–0.69	0.93	0.84–0.97	0.70–0.99
	Composite adverse outcome	3	211	0.34	0.18–0.55	0.10–0.69	0.96	0.77–0.99	0.45–1.00
MCA‐PI; < 5th percentile17	ED for fetal distress	3	416	0.35	0.22–0.49	0.16–0.59	0.83	0.78–0.87	0.77–0.87
	NICU admission	3	270	0.64	0.10–0.99	0.02–0.99	0.75	0.67–0.81	0.51–0.89
	Composite adverse outcome	3	511	0.67	0.58–0.74	0.55–0.75	0.78	0.59–0.89	0.39–0.95

ED, emergency delivery; NICU, neonatal intensive care unit; PI, pulsatility index; predict int, prediction interval; RI, resistance index.