Table 2.
Drug utilization in CCAE
| 3 months | 6 months | 12 months | ||||
|---|---|---|---|---|---|---|
| Variable | Proxy TRD | No TRD | Proxy TRD | No TRD | Proxy TRD | No TRD |
| Mean number of antidepressants | 1.81 | 1.15 | 2.16 | 1.29 | 2.62 | 1.50 |
| Mean number of antipsychotics | 0.58 | 0.07 | 0.69 | 0.08 | 0.83 | 0.09 |
| Mean number of psychotherapies | 0.38 | 0.17 | 0.47 | 0.20 | 0.58 | 0.25 |
| Mean number of antidepressants with adequate dose | 0.40 | 0.21 | 0.69 | 0.35 | 1.09 | 0.55 |
| Mean number of antidepressants with eras of at least 30 days | 0.72 | 0.39 | 1.24 | 0.64 | 1.93 | 1.03 |
| Definition in which the maximum time within a new treatment must begin before the original treatment can be considered a failure is 90 days (%) | 22.3 | 2.7 | 35.5 | 5.3 | 45.5 | 8.5 |
| Definition in which the maximum time within a new treatment must begin before the original treatment can be considered a failure is 90 days and only considers a treatment a failure if the dose is adequate (%) | 19.9 | 2.0 | 32.3 | 3.7 | 40.3 | 5.7 |
| Definition in which no limit is place within a new treatment must begin before the original treatment can be considered a failure (%) | 22.3 | 2.7 | 41.0 | 7.2 | 57.2 | 14.2 |
| Definition in which the maximum time within a new treatment must begin before the original treatment can be considered a failure is 180 days (%) | 22.3 | 2.7 | 41.0 | 7.2 | 52.7 | 11.9 |
| Definition in which the maximum time within a new treatment must begin before the original treatment can be considered a failure is 180 days and only considers a treatment a failure if the dose is adequate (%) | 19.9 | 2.0 | 37.3 | 5.0 | 47.0 | 7.9 |
Notes:
TRD: Treatment‐resistant depression