Table 3.

Univariate and multivariate analysis of Hsp70 and other relevant variables as prognostic factors for local progression‐free survival (LPFS)

	Univariate				Multivariate
	HR	CIlow	CIupp	p‐Value	HR	CIlow	CIupp	p‐Value
Hsp70 (scores 3–4 vs. 0–2)	1.84	1.05	3.22	0.034*	2.63	1.45	4.78	0.002*
Age	0.98	0.96	1.01	0.180
Gender (female vs. male)	1.54	0.90	2.61	0.113
Tumor site				<0.001*				0.088
Oropharynx vs. oral cavity	0.39	0.24	0.64	0.0002*	0.63	0.32	1.22	0.172
Hypopharynx vs. oral cavity	0.35	0.17	0.75	0.006*	0.39	0.16	0.97	0.042*
pT stage (3–4 vs. 1–2)	2.23	1.42	3.52	0.0005*	1.94	1.09	3.44	0.022*
pN stage (2–3 vs. 0–1)	1.10	0.65	1.87	0.730
Grading (3 vs. 1–2)	0.75	0.47	1.21	0.243
Resection margin (ECE)	1.60	1.00	2.54	0.050	1.97	1.05	3.70	0.035*
HPV16 DNA (pos vs. neg)	0.33	0.18	0.61	0.0004*	0.32	0.12	0.88	0.028*
p16 (pos vs. neg)	0.38	0.22	0.67	0.0008*	0.53	0.22	1.28	0.158
p53 (pos vs. neg)	1.86	1.18	2.92	0.007*	0.90	0.48	1.68	0.774
Smoking history (yes vs. no)	0.84	0.58	1.22	0.368

Abbreviations: HR, hazard ratio; CI_low/upp, lower and upper 95% confidence interval.

Bold values marked with * present p‐values <0.05 and are considered as statistically significant.