Table 4.

Univariate and multivariate analysis of Hsp70 and other relevant variables as prognostic factors for distant metastases‐free survival (DMFS)

	Univariate				Multivariate
	HR	CIlow	CIupp	p‐Value	HR	CIlow	CIupp	p‐Value
Hsp70 (scores 3–4 vs. 0–2)	1.76	1.01	3.07	0.044*	2.42	1.34	4.37	0.003*
Age	0.99	0.97	1.02	0.443
Gender (female vs. male)	1.06	0.60	1.86	0.842
Tumor site				0.001*				0.629
Oropharynx vs. oral cavity	0.40	0.25	0.65	0.0002*	0.73	0.37	1.42	0.350
Hypopharynx vs. oral cavity	0.55	0.28	1.08	0.081	0.88	0.39	2.01	0.763
pT stage (3–4 vs. 1–2)	2.19	1.39	3.42	0.0006*	1.90	1.09	3.31	0.024*
pN stage (2–3 vs. 0–1)	1.26	0.73	2.14	0.425
Grading (3 vs. 1–2)	0.87	0.55	1.38	0.563
Resection margin (ECE)	1.89	1.18	3.01	0.008*	2.51	1.33	4.75	0.005*
HPV16 DNA (pos vs. neg)	0.35	0.19	0.63	0.0005*	0.35	0.13	0.97	0.044*
p16 (pos vs. neg)	0.36	0.20	0.63	0.0002*	0.44	0.18	1.10	0.080
p53 (pos vs. neg)	1.78	1.14	2.78	0.012*	0.86	0.46	1.60	0.631
Smoking history (yes vs. no)	0.81	0.56	1.17	0.261

Abbreviations: HR, hazard ratio; CI_low/upp, lower and upper 95% confidence interval.

Bold values marked with * present p‐values <0.05 and are considered as statistically significant.