Table 5.

Univariate and multivariate analysis of tumor‐infiltrating CD56⁺ NK cells and other relevant variables as prognostic factors for overall survival (OS)

	Univariate				Multivariate
	HR	CIlow	CIupp	p‐Value	HR	CIlow	CIupp	p‐Value
CD56 (high vs. low)	0.29	0.15	0.55	0.0001*	0.27	0.12	0.60	0.001*
Tumor site
Oropharynx vs. oral cavity					0.86	0.35	2.07	0.732
Hypopharynx vs. oral cavity					0.56	0.15	2.05	0.381
pT stage (3–4 vs. 1–2)					2.33	1.12	4.79	0.022*
Resection margin (ECE)					2.28	0.92	5.65	0.075
HPV16 DNA (pos vs. neg)					0.29	0.07	1.10	0.070
p16 (pos vs. neg)					0.60	0.20	1.85	0.377
p53 (pos vs. neg)					1.06	0.46	2.48	0.885

Abbreviations: HR, hazard ratio; CI_low/upp, lower and upper 95% confidence interval.

Bold values marked with * present p‐values <0.05 and are considered as statistically significant.