Table 1.
2017 WHO classification of neuroendocrine carcinomas of larynx [4]
| Tumor type | Grade | Diagnostic criteria | % 5-year DSS {6414} (%) |
|---|---|---|---|
| Well-differentiated NEC (WD-NEC) | 1 | Features of neuroendocrine differentiation Minimal nuclear atypia < 2 mitoses/10 HPFs or 2 mm2 |
100 |
| Moderately-differentiated NEC (MD-NEC) |
2 | Necrosis and/or 2–10 mitoses/10 HPFs or 2 mm2 |
52.8 |
| Poorly-differentiated NEC (PD-NEC) | > 10 mitoses/10 HPFs or 2 mm2 | ||
| Small-type (SC-NEC) | 3 | 19.3 | |
| Large-cell type (LC-NEC) | 3 | 15.3 |
DSS disease specific survival