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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: Hum Genet. 2017 Jun 29;136(9):1079–1091. doi: 10.1007/s00439-017-1826-3

Figure 2. Proteins generated from the 5HT2C gene.

Figure 2

A. Protein sequence of human 5HT2C_tr. The transmembrane spanning helices are indicated. The black amino acid marks the C23S polymorphism that is associated with suicide.

B. Protein sequence of human 5HT2C_FL receptor. The blue marked amino acids SSV at the C-terminus are a PDZ-ligand (Becamel et al. 2004). The amino acids changed through RNA editing are shown in red, green and blue and enlarged in panel E.

C. Localization of 5HT2C_tr, which is only associates with internal membranes, likely the endoplasmic reticulum (ER), indicated as an orange oval.

D. Localization of the 5HT2C_FL receptors that shuttle between internal membranes, likely endoplasmic reticulum (ER, orange) and the plasma membrane.

E. Effect of RNA editing on amino acids encoded by 5HT2C and effect on receptor activity. The amino acids changed by editing are highlighted in B. The effect of RNA editing on signaling is shown on the right.