Table 3. Hazard of women with polycystic ovary syndrome (PCOS) developing nonalcoholic fatty liver disease (NAFLD) compared to women without PCOS.
| Primary analysis | Sensitivity analysis (Incident cases) | Sensitivity analysis (PCOS-specific Read codes only) |
||||
|---|---|---|---|---|---|---|
| PCOS (Exposed) |
Controls (Unexposed) |
PCOS (Exposed) |
Controls (Unexposed) |
PCOS (Exposed) |
Controls (Unexposed) |
|
| Total number of participants | 63,210 | 121,064 | 20,162 | 37,544 | 19,425 | 35,967 |
| Person years | 297,842 | 576,065 | 94,778 | 167,009 | 84,041 | 149,852 |
| Incident NAFLD n (%) | 274 (0.43) | 222 (0.18) | 80 (0.40) | 65 (0.17) | 83 (0.43) | 64 (0.18) |
| Incidence rates per 10,000 person years | 9.2 | 3.9 | 8.4 | 3.9 | 9.9 | 4.3 |
| Hazard ratio (95% CI) | 2.38 (1.99–2.84) | 2.15 (1.55–2.99) | 2.24 (1.62–3.11) | |||
| p-value | <0.001 | <0.001 | <0.001 | |||
| Baseline adjusted hazard ratio (95% CI)* | 2.23 (1.86–2.66) | 2.07 (1.49–2.87) | 2.10 (1.52–2.93) | |||
| p-value | <0.001 | <0.001 | <0.001 | |||
| Follow-up adjusted hazard ratio (95% CI)† | 2.14 (1.79–2.56) | 1.98 (1.43–2.75) | 2.04 (1.47–2.84) | |||
| p-value | <0.001 | <0.001 | <0.001 | |||
*Adjusted for age, Townsend score, BMI, diabetes or impaired glucose regulation, and hypothyroidism.
†Adjusted for age, Townsend score, BMI, diabetes or impaired glucose regulation up to end of follow-up, and hypothyroidism at baseline.