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. 2018 Mar 5;52(5):1528–1538. doi: 10.3892/ijo.2018.4299

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Copyright: © Zhong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Rituximab elevates the level of IL-17A and the percentages of Th17 cells and IL-17⁺Foxp3⁺ Treg cells in the peripheral blood mononuclear cells (PBMCs) from patients with diffuse large B cell lymphoma (DLBCL). (A and B) Representative FACS plots of Th17 cells and IL-17⁺Foxp3⁺ Treg cells in the PBMCs from each group. The numbers displayed are the percentages of Th17 cells and IL-17⁺Foxp3⁺ Treg cells. (C and D) Graphs of the Th17 cells and IL-17⁺Foxp3⁺ Treg cell percentages in each group. (E-H) Graphs of the levels of IL-17A, IL-6, IL-21 and TGF-β in each group. Error bars represent standard deviation (SD). Significance was determined using single-factor analysis of variance (one-way ANOVA) with Student-Newman-Keuls/Dunnett's T3 test (3 groups). ^*P<0.05, compared with the DLBCL, CHOP-CR or CHOP-NCR group. CR, complete remission; NCR, no complete remission.