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. 2018 Feb 26;128(4):1384–1396. doi: 10.1172/JCI97611

Figure 8. Reduced CADM1 expression is correlated to worse patient survival and metastasis.

Figure 8

(A) The lung adenocarcinoma patient cohort of Shedden et al. (41) (Lung n = 442) was stratified into groups expressing low and high CADM1 and was assessed for overall survival. (B and C) The Shedden et al. data set is further classified into subgroups based on tumor stage and nodal status recorded at the time of diagnosis. Mean CADM1 expression and its distribution are depicted in the violin plots with box-and-whisker overlays in white. Two-tailed, unpaired t tests were performed, *P < 0.05; **P < 0.01. (D) The lung adenocarcinoma patient cohort of Györffy et al. (42) (Lung n = 720) was stratified into groups expressing low and high CADM1 and was assessed for overall survival. (E) The breast carcinoma patient cohort of Györffy et al. (43) [estrogen receptor–positive (ER+) breast n = 548] was stratified into groups expressing low and high CADM1 and was assessed for overall survival. (A, D, and E) Data sets shown here are Kaplan-Meier survival curves with log-rank P values comparing the groups.