Figure 1. A broad clinical spectrum of VMs in somatic RAS/MAPK mutations.

Inexorable enlargement of high-flow AVMs with age, affecting the face and leading to loss of vision in the right eye (A–D), and affecting the right ear helix and posterior auricular soft tissues leading to eventual resection of the helix (E–G). Varied clinical examples of the spectrum of high-flow VMs (AVMs) of the temple, left leg/buttock, and left face (H and I). Segmental overgrowth of the left arm, chest wall, and breast with a colocalized low-flow VM, detectable by a uniform brownish-pink macular capillary malformation and superimposed scattered telangiectasia, with clear midline demarcation (J–L). Segmental overgrowth of the right arm and hand, with a colocalized uniform brownish-pink capillary malformation with superimposed scattered telangiectasia (M and N).