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. 2018 Mar 5;128(4):1397–1412. doi: 10.1172/JCI97650

Figure 8. Activation of EGFR signaling in the kidneys of Fcgr2b–/– mice was diminished by iRhom2 deficiency.

Figure 8

(A) Kidney expression of p-EGFR and p-ERK1/2. Total ERK1/2 was used as control (n = 4 WT, n = 4 Rhbdf2–/–, n = 9 Fcgr2b–/–, n = 9 Fcgr2b–/–Rhbdf2–/– mice). (B) Kidney expression of EGFR ligands and the Egfr gene on RNA-seq (n = 4 mice per group) and renal Hbegf expression measured by qPCR (n = 4 WT, n = 4 Rhbdf2–/–, n = 8 Fcgr2b–/–, n = 8 Fcgr2b–/–Rhbdf2–/– mice). Data are shown as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, 1-way ANOVA with Dunnett’s multiple comparisons test. ND, not detected.