Figure 1. Strategies targeting cellular senescence.

Three principal approaches could be implemented to block deleterious effects of senescent cells. (A) The leading options are strategies that induce apoptosis selectively in senescent cells with the use of senolytic drugs, which block prosurvival pathways. (B) The second type of strategy is to potentiate an immune response against senescent cells in a way that would lead to their clearance from tissues. (C) A third strategy proposes specific blockade of SASP components by targeting of their upstream regulators and effectors. ADCC, antibody-dependent cell-mediated cytotoxicity; DDR, DNA damage response; GOS, galacto-oligosaccharides; ITAM, immunoreceptor tyrosine-based activation motif.