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. 2018 Mar 19;128(4):1657–1670. doi: 10.1172/JCI94331

Figure 8. Suggested model of RTX mechanism in rodent, canine, and human.

Figure 8

RTX acts at the level of the spinal cord to ablate only the centrally projecting axon of TRPV1-expressing C and Aδ neurons. The neuronal cell bodies in the DRG and the peripherally projecting axonal portion of the neurons are not bathed in drug-containing CSF and remain intact and functional. The TRPV1+ axons are only a subpopulation of the somatosensory and proprioceptive afferent populations. Only the TRPV1+ population is susceptible.