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. 2018 Mar 16;52(5):1415–1426. doi: 10.3892/ijo.2018.4324

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Global signal transduction network of regulated genes following BRD4 knockdown. Red circles represent upregulated genes, and blue circles represent downregulated genes. Circles with green rings represent the genes that were selected to be experimentally validated. The area of the circle represents the degree, which is defined as the number of binding genes. A higher degree indicated that the gene had a strong correlation with other genes. The line exhibits the interaction between the genes. BRD4, bromodomain containing 4; a, activation; dep, dephosphorylation; pho, phosphorylation; ex, expression; b (a), binding-association; inh, inhibition; ind (e), indirect effect; c, compound; ubi, ubiquitination; dis, dissociation.