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. 2018 Mar 5;52(5):1515–1527. doi: 10.3892/ijo.2018.4304

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Bioinformatics analysis. (A) Cluster analysis of the differentially expressed miRNAs between colon cancer tissues ('C') and adjacent tissues ('N'). A total of 10 significant differentially expressed miRNAs (|log fold change|>1.5 and P<0.05) are highlighted in green (downregulated) and red (upregulated). (B) Overlap analysis of miRanda, MicroCosm and differentially expressed miRNAs. miR-34c-5p and miR-34a are most likely to interact with the 3′-untranslated region of SIRT6 mRNA. (C) Potential binding sites of miR-34c-5p and SIRT6 mRNA. miR, microRNA; SIRT6, sirtuin 6.