Table III.

Univariate and multivariate survival analyses.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Sirtuin 6 expression	0.475	0.282–0.799	0.005a	0.531	0.301–0.936	0.029a
Sex	1.052	0.627–1.763	0.849
Age (years)	1.955	1.132–3.373	0.016a	2.399	1.297–4.437	0.005a
T stage	1.540	0.861–2.754	0.146
N stage	2.233	1.553–3.213	<0.001a	1.808	0.823–3.971	0.140
M stage	13.908	3.680–46.626	<0.001a	1.972	0.424–9.173	0.387
TNM stage	2.790	1.756–4.431	<0.001a	1.136	0.441–2.926	0.791
Grade	2.664	1.653–4.296	<0.001a	2.033	1.221–3.386	0.006a

^aP<0.05. CI, confidence interval; HR, hazard ratio.