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. 2018 Mar 5;128(4):1429–1441. doi: 10.1172/JCI91086

Figure 5. Osteoclast-derived SLIT3 is indispensable for normal bone mass in vivo.

Figure 5

(A) Micro-CT analyses of the femurs of 16-week-old male Slit3nestin–/– mice and their Slit3fl/fl littermates (n = 4–5 per group). (B) Micro-CT analyses of the femurs of 16-week-old male Slit3col2.3–/– mice and their Slit3fl/fl littermates (n = 4–6 per group). (C) Micro-CT analyses of the femurs of 16-week-old male Slit3ctsk–/– mice and their Slit3fl/fl littermates (n = 4–5 per group). (D) Von Kossa staining and histomorphometric analyses including calcein double-labeling of the femurs of 16-week-old male Slit3ctsk–/– mice and their Slit3fl/fl littermates (n = 4–5 per group). Scale bars: 500 μm (left panels); 10 μm (right panels). Data are presented as mean ± SEM. *P < 0.05 vs. littermate control using the Mann-Whitney U test.