Figure 6. Local and abscopal effects of intratumoral NDV in combination with systemic PD-1 or PD-L1 blockade.
B16-F10 tumors were implanted by i.d. injection of 4 × 105 B16-F10 cells into the right flank and 5 × 104 cells into the left flank on day 0. On days 3, 5, 7, and 9, mice were treated with intratumoral injections of NDV or PBS and concomitant i.p. injections of anti–PD-1, anti–PD-L1, or isotype control antibody. (A) Growth of NDV-treated tumors. (B) Growth of distant tumors. (C) Overall survival. (D) Rechallenge of surviving animals at 90 days. (A and B) Data represent 1 of 2 experiments with 10 mice per group. (C and D) Data represent 2 pooled experiments with 10 mice per group. **P < 0.01, ***P < 0.001, and ****P < 0.0001, by log-rank test (C and D).