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. 2018 Apr 2;128(4):1238–1246. doi: 10.1172/JCI95148

Figure 2. Molecular pathways controlling growth arrest during senescence.

Figure 2

A variety of stressors induce senescence-associated growth arrest. Cell cycle exit is regulated by induction of the p16INK4a/Rb and p53/p21CIP1 pathways. Figure reproduced with permission from McHugh and Gil (126).