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. 2018 Feb 26;128(4):1371–1383. doi: 10.1172/JCI96153

Figure 2. Timing of somatic alterations and driver acquisition in metastases.

Figure 2

Somatic DNA alterations within a single patient classified into 4 categories on the basis of a hypothesized timing with which they were acquired during the development of metastasis. (A) Founder alterations established in the primary tumor and observed in all metastases (gray), shared in the primary tumor and metastases but not in all tumors (purple), shared in 2 metastases but not the primary tumor (pink), and private to 1 metastasis (blue). The distributions of all (B) somatic mutations, (C) somatic CNAs, (D) DawnRank predicted mutations, and (E) DawnRank CNAs within each patient. shared primary/mets, shared in the primary tumor and metastases but not in all tumors; shared met-met, shared in 2 metastases but not the primary tumor.