Table 2.
Time dependent Cox extended models for the risk of having lower respiratory tract infection during follow-up, INI cohort, 2000–2015
| Unadjusted HR (95% CI) | Adjusted HR (95% CI) | |
|---|---|---|
| Sex | ||
| Male | Ref. | Ref. |
| Female | 1.04 (0.83, 1.29) | 1.07 (0.85, 1.34) |
| Age category (in years)a | ||
| <30 | Ref. | Ref. |
| 30–39 | 0.92 (0.68, 1,26) | 0.92 (0.67, 1.25) |
| 40–49 | 0.73 (0.52, 1.01) | 0.73 (0.53, 1.02) |
| 50–59 | 0.94 (0.65, 1.37) | 0.96 (0.66, 1.41) |
| 60+ | 1.40 (0.90, 2.18) | 1.44 (0.92, 2.26) |
| Race/skin color | ||
| White | Ref. | |
| Non-white | 1.28 (1.05, 1.58) | 1.14 (0.93, 1.41) |
| Educational level | ||
| Up to 9 years | Ref. | |
| More than 9 years | 0.61 (0.49, 0.75) | 0.84 (0.67, 1.06) |
| Cocaine use | ||
| No | Ref. | Ref |
| Yes | 2.01 (1.52, 2.65) | 1.47 (1.07, 2.02) |
| Tobacco smoking (ever) | ||
| No | Ref. | Ref. |
| Yes | 1.30 (1.04, 1.62) | 1.23 (0.99, 1.53) |
| Alcohol drinking | ||
| No | Ref. | |
| Yes | 1.16 (0.90, 1.49) | |
| Diabetes mellitus | ||
| No | Ref. | |
| Yes | 1.07 (0.79, 1.46) | |
| Hepatitis C | ||
| No | Ref. | Ref. |
| Yes | 1.51 (1.09, 2.10) | 1.14 (0.80, 1.63) |
| CD4 counta (per 100cells/mm3 increase) | 0.81 (0.77, 0.85) | 0.86 (0.82, 0.91) |
| Last year HIV viral load (copies/mL) | ||
| <400 | Ref. | Ref. |
| ≥400 | 3.40 (2.67, 4.33) | 2.20 (1.70, 2.86) |
| Missing | 1.21 (0.86, 1.71) | 0.99 (0.69, 1.41) |
| Influenza vaccinationa | ||
| No | Ref. | Ref. |
| Yes | 0.60 (0.46, 0.79) | 0.81 (0.61, 1.08) |
| PPVS23 vaccinationa | ||
| No | Ref. | Ref. |
| Yes | 0.57 (0.45, 0.70) | 0.81 (0.64, 1.03) |
Bold values indicate statistical significance
INI Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil, HR hazard ratio, CI confidence interval, PPSV23 pneumococcal polysaccharide
a
Variables included in the model as time-dependent