Table 1.
Pancreatic Cancer Predisposing Genes
| Genes | Predisposition Syndromes | Risk of Pancreatic Cancer† |
|---|---|---|
| BRCA2 | Hereditary breast and/or ovarian cancer | SIR = 2.20 – 5.90 |
| BRCA1 | SIR = 1.60 – 4.73 | |
| PALB2 | Familial breast cancer | Increased |
| ATM | Increased | |
| STK11 | Peutz-Jeghers syndrome | SIR = 76.2 – 139.7 |
| PRSS1 | Hereditary Pancreatitis | SIR = 53 – 87 |
| CDKN2A | Familial atypical multiple mole and melanoma syndrome | SIR = 14.8 – 80.8 |
| Mismatch repair genes (MLH1, MSH2, MHS6 and PMS2) | Hereditary non-polyposis colorectal cancer | No effect up to SIR = 10.68 |
†
SIR = standardized incidence ratio