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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Bioessays. 2018 Feb 6;40(3):10.1002/bies.201700208. doi: 10.1002/bies.201700208

Figure 1. Eukaryotic CMG helicase and orientation to other proteins in a replisome.

Figure 1

a) Top view (left) and side view (right) of CMG, indicating the Mcm2-7 motor ring and the Cdc45 and GINS accessory factors (PDB ID 3JC5). b) Selected EM 2D averages of CMG in side view, with additional proteins as indicated (adapted with permission from Fig. 5 in [39]). c) Illustration of the core eukaryotic replisome, see text for details.