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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Environ Int. 2018 Feb 6;113:133–142. doi: 10.1016/j.envint.2018.01.015

Table 4.

Associations of OCM SNPs with urinary As metabolite percentages.

Urinary %InAsa Urinary %MMAa Urinary %DMAa
Gene SNP Ref. allele Risk allele B (SE) p FDR B (SE) p FDR B (SE) p FDR
MTHFR rs1801133 C T 0.070 (0.023) 0.002 0.04 −0.060 (0.024) 0.01 0.16
MTR rs1805087 A G 0.039 (0.019) 0.04 0.30 −0.034 (0.017) 0.05 0.37
SHMT1 rs1979277 G A 0.050 (0.023) 0.03 0.30
a

Beta regression model (with logit link) with SNP predictor (additive coding with AA, Aa, aa coded as 0, 1, and 2, respectively), adjusted for sex, age, log wAs, and education (categorical)