Table 5.

Interactions of OCM SNPs and water As on odds for incident skin lesions in conditional logistic regression models.

Gene	SNP	Pairs (n)	Ref. allele	Risk allele	SNP B (95% CI)^a	Log wAs B (95% CI)^a	SNP*Log wAs B (95% CI)^a	p^b	FDR
AS3MT	rs3740393	557	G	C	−0.05 (−0.27, 0.18)	0.19 (0.10, 0.27)	0.07 (−0.05, 0.19)	0.25	0.63
BHMT	rs3733890	548	G	A	−0.10 (−0.31, 0.10)	0.23 (0.13, 0.32)	−0.01 (−0.11, 0.09)	0.83	0.96
FOLR1	rs1540087	548	C	T	−0.07 (−0.45, 0.30)	0.19 (0.11, 0.26)	0.25 (0.03, 0.47)	0.02	0.15
FOLR2	rs2298444	557	A	G	0.11 (−0.08, 0.30)	0.16 (0.05, 0.26)	0.08 (−0.02, 0.18)	0.10	0.38
FOLR2	rs651646	554	A	T	−0.06 (−0.24, 0.13)	0.21 (0.10, 0.32)	0.02 (−0.08, 0.11)	0.75	0.96
MTHFD1	rs11627387	538	G	A	0.15 (−0.05, 0.35)	0.20 (0.10, 0.29)	0.04 (−0.07, 0.14)	0.47	0.88
MTHFD1	rs1950902	561	C	T	0.15 (−0.14, 0.44)	0.22 (0.14, 0.30)	−0.02 (−0.16, 0.12)	0.79	0.96
MTHFR	rs1801133	556	C	T	−0.17 (−0.44, 0.10)	0.24 (0.16, 0.32)	−0.10 (−0.23, 0.04)	0.16	0.48
MTR	rs1805087	556	A	G	−0.01 (−0.22, 0.19)	0.22 (0.13, 0.31)	0.00 (−0.11, 0.10)	0.99	0.99
MTRR	rs1801394	554	A	G	−0.03 (−0.20, 0.15)	0.10 (−0.02, 0.22)	0.11 (0.02, 0.21)	0.02	0.15
SHMT1	rs1979277	543	G	A	0.01 (−0.23, 0.24)	0.22 (0.13, 0.30)	−0.02 (−0.14, 0.11)	0.76	0.96
SLC19A1	rs1888530	546	T	C	−0.07 (−0.25, 0.11)	0.22 (0.10, 0.34)	0.00 (−0.09, 0.09)	0.92	0.99
SLC46A1	rs1128162	536	T	G	−0.05 (−0.23, 0.13)	0.25 (0.13, 0.37)	−0.03 (−0.12, 0.07)	0.56	0.93
TCN2	rs1801198	557	G	C	0.13 (−0.06, 0.33)	0.25 (0.14, 0.35)	−0.04 (−0.13, 0.05)	0.44	0.88
TYMS	rs1001761	550	C	T	0.11 (−0.08, 0.29)	0.12 (0.00, 0.24)	0.09 (0.00, 0.18)	0.06	0.30

Conditional logistic regression model with predictors SNP (additive coding with AA, Aa, aa coded as 0, 1, and 2, respectively), log-transformed wAs centered at its median (log(71.5 μg/L)), and SNP × log-transformed wAs cross-product term, adjusted for age and education (categorical);

p-value and FDR for cross-product term