Table 6.
Joint effects of OCM genotypes with water As exposures on odds for incident skin lesions in conditional logistic regression models.
| Gene | SNP | Level | wAs < 50 μg/L OR (95% CI)a |
wAs ≥ 50 μg/L OR (95% CI)a |
|---|---|---|---|---|
| MTRR | rs1801394 | AA | ref. | 1.47 (0.87, 2.47) |
| AG | 0.76 (0.46, 1.26) | 1.44 (0.91, 2.29) | ||
| GG | 0.53 (0.30, 0.92) | 1.75 (1.06, 2.90) | ||
|
| ||||
| FOLR1 | rs1540087 | CC | ref. | 1.93 (1.46, 2.55) |
| CT/TT | 0.54 (0.29, 0.98) | 2.23 (1.34, 3.72) | ||
|
| ||||
| TYMS | rs1001761 | CC | ref. | 1.50 (0.89, 2.54) |
| CT | 0.88 (0.54, 1.43) | 1.85 (1.16, 2.94) | ||
| TT | 0.77 (0.45, 1.32) | 2.18 (1.31, 3.63) | ||
a
Conditional logistic regression model with listed categorical SNP/wAs predictor, adjusted for age and education