Table 5. Association of each pg/mgCr increase in log urinary klotho-to-creatinine ratio and diffuse foot process effacement.

	Diffuse effacement of foot process
Log UKCR	Odds ratio	P-value
Model 1a	0.558 (0.374–0.790)	0.002
Model 2b	0.460 (0.256–0.733)	0.003
Model 3c	0.450 (0.224–0.778)	0.010

Presented as odds ratios (95% confidence interval) based on multivariable logistic regression. Foot process effacement of podocyte was grouped according to absent/focal effacement (effacement <70%) and diffuse effacement (effacement ≥70%). Log-transformed urinary klotho-to-creatinine ratio was treated as a continuous variable (pg/mgCr). UKCR: urinary klotho-to-creatinine ratio.

^aModel 1: not adjusted

^bModel 2: adjusted for age, gender, and body mass index

^cModel 3: adjusted for Model 2 variables plus diabetes mellitus, hypertension, estimated glomerular filtration rate, and interstitial fibrosis.