Fig 4. Receiver operator curves using the developed Shigella CHIM disease severity score to predict two separate dichotomous endpoints of shigellosis.

Footnote: Receiver operator curves using a Shigella disease score to predict two separate dichotomous endpoints as follows. Endpoint 1 (solid line): diarrhea (≥2 loose stools ≥200 grams over 48 hours or a single loose stool ≥300 grams) OR fever (oral temperature ≥100.0°F) OR gross blood confirmed by hemoccult in ≥1 loose stool; Endpoint 2 (dashed line): severe diarrhea (≥6 loose stools in 24 hours or >800 grams of loose stool in 24 hours) OR moderate diarrhea (4–5 loose stools in 24 hours or 401–800 grams of loose stool in 24 hours) AND [fever (oral temperature >100.4°F) or with moderate enteric/constitutional symptoms (nausea, vomiting, abdominal cramps/pain, myalgia, arthralgia, rigors, tenesmus, fecal urgency)] OR gross blood confirmed by hemoccult in ≥2 loose stools in 24 hours and enteric/constitutional symptoms (nausea, vomiting, abdominal cramps/pain, myalgia, arthralgia, rigors, tenesmus, fecal urgency).