Table 3. Frequency (percent) of Shigella-attributed signs and symptoms in four CHIMs with S. flexneri 2a strain 2457T.
| Mild | Moderate | Severe | Any | |
|---|---|---|---|---|
| Diarrhea1 | 7.4 | 24.1 | 44.4 | 75.9 |
| Fever2 | 9.3 | 11.1 | 29.6 | 50.0 |
| Nausea3 | 13.0 | 16.7 | 16.7 | 46.3 |
| Abdominal pain/cramps3 | 22.2 | 20.4 | 38.9 | 81.5 |
| Malaise3 | 10.6 | 4.3 | 42.6 | 57.4 |
| Headache3 | 22.2 | 14.8 | 9.3 | 66.7 |
| Myalgia3 | 13.0 | 11.1 | 18.5 | 42.6 |
| Arthralgia3 | 3.7 | 9.3 | 7.4 | 20.4 |
| Anorexia3 | 25.9 | 9.3 | 29.6 | 64.8 |
| Vomiting | 24.1 | |||
| Dysentery4 | 27.8 | |||
1. mild, 2–3 loose stools in 24 hrs totaling <400 ml; moderate, 4–5 loose stools in 24 hrs or 401–800 ml loose stool in 24 hrs; severe, ≥6 loose stools in 24 hrs or > 800 ml loose stool in 24 hrs
2. mild, >100.4°F; moderate, >101.1°F; severe, >102.1°F
3. mild, does not interfere with normal activities; moderate, interferes with normal activities; severe, prevents normal activities
4. gross blood in multiple loose stools confirmed by hemoccult