Table 2. Cox regression analyses for the risk of interim CVD for each biomarker.
| Age-/sex-adjusted | Multiple factor-adjusted | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number of participants | Number of incidents | HR | 95% CI | p-values | HR | 95% CI | p-values | ||
| UACR | Q1 | 1439 | 46 | 1.00 | 1.00 | ||||
| Q2 | 1439 | 53 | 1.07 | (0.72–1.59) | 0.726 | 1.04 | (0.70–1.55) | 0.842 | |
| Q3 | 1439 | 82 | 1.85 | (1.29–2.67) | 0.001* | 1.70 | (1.18–2.45) | 0.005* | |
| Q4 | 1438 | 106 | 2.28 | (1.61–3.24) | <0.001* | 1.91 | (1.33–2.74) | <0.001* | |
| p for trend | <0.001* | p for trend | <0.001* | ||||||
| BNP | Q1 | 1442 | 54 | 1.00 | 1.00 | ||||
| Q2 | 1441 | 42 | 0.82 | (0.55–1.23) | 0.332 | 0.82 | (0.55–1.23) | 0.327 | |
| Q3 | 1441 | 63 | 1.22 | (0.85–1.76) | 0.285 | 1.20 | (0.83–1.73) | 0.327 | |
| Q4 | 1431 | 128 | 2.47 | (1.78–3.42) | <0.001* | 2.16 | (1.53–3.06) | <0.001* | |
| p for trend | <0.001* | p for trend | <0.001* | ||||||
| hsCRP | Q1 | 1384 | 66 | 1.00 | 1.00 | ||||
| Q2 | 1330 | 61 | 0.93 | (0.66–1.32) | 0.702 | 0.90 | (0.63–1.28) | 0.544 | |
| Q3 | 1654 | 67 | 0.81 | (0.57–1.13) | 0.215 | 0.73 | (0.51–1.04) | 0.080 | |
| Q4 | 1387 | 93 | 1.33 | (0.97–1.83) | 0.076 | 1.11 | (0.79–1.55) | 0.551 | |
| p for trend | 0.013* | p for trend | 0.068 | ||||||
HR, hazard ratio; CI, confidence interval; CVD, cardiovascular disease; UACR, urinary albumin-creatinine ratio; BNP, B-type natriuretic peptide; hsCRP, high-sensitivity C-reactive protein.
Adjusted by age, sex, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, blood hemoglobin, HabA1c, estimated glomerular filtration rate, duration of education, atrial fibrillation, smoking status and drinking status.
* Statistically significant