Fig 6. Change in pharmacodynamic parameters following administration of andexanet in edoxaban-anticoagulated rabbits.

(A) Edoxaban anti-FXa activity was measured by a modified anti-FXa activity assay. The anti-FXa activity in unknown samples was quantified using the known concentrations of edoxaban in rabbit plasma as standards and expressed as ng/mL. Data are plotted as mean ± standard deviation. (B) PT measurements in seconds. (C) aPTT measurements in seconds. Determination of PT and aPTT was performed on an Instrumentation Laboratory ACL Elite. HemosIL PT-Fibrinogen kit was used for PT measurements, and HemosIL SynthASil kit was used for aPTT measurements.