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. 2001 Sep 18;98(20):11399–11404. doi: 10.1073/pnas.191268198

Figure 1.

Figure 1

Comparison of genomic nucleotide sequences around the 92-bp exon of various primate CMP-Neu5Ac hydroxylase genes. Hs, Pt, Gg, and Mm refer to the human, chimpanzee, gorilla, and rhesus monkey, respectively. The shaded boxes represent the 92-bp exon deleted in the hominid lineage. The Alu element is represented by the open box. The direct repeats of the sialic acid hydroxylase AluSq (sahAluSq) are underlined. The arrowheads indicate replacement boundaries. The 5′-TAAAGATTAATTTTTATTTTT-3′ sequence, which would have a strong preference to the target-priming by the Alu poly(A) tail, is located in the 5′ region immediately adjacent to the upstream replacement boundary. Dots refer to identical nucleotides in the other primates; dashes indicate gaps used for sequence alignment. In the gap corresponding to the human deletion, the complete sequences of the other primate genes are shown.