Table.

PCP Component	Function in Wnt/PCP Signaling	Cancer Type	Contribution to Tumorigenesis	Reference
WNT5A	Secreted ligand, activates Wnt/PCP signaling		Promote or suppress in context dependent manner
		Breast	Promote cell migration and invasiveness	[25],[26]
		Gastric	Promote cell migration and invasiveness	[27]
		Melanoma	Promote cell motility and invasiveness	[32]
		Colon	Suppress cell proliferation and EMT	[36]
		Hematopoeitic Malignancies	Suppress cell proliferation (inhibit canonical Wnt signaling)	[38]
		Thyroid Carcinoma	Suppress cell proliferation, migration, and invasiveness (inhibits canonical Wnt signaling	[39]
WNT11	Secreted ligand, activates Wnt/PCP signaling		Promote or suppress in context dependent manner
		Breast	Promote cell motility and tumor metastasis	[22]
		Colon	Promote cell proliferation, migration and invasiveness	[30]
		Prostate	Promote cell differentiation, survival and migration	[31]
		Hepatocellular Carcinoma	Supress cell proliferation and migration (inhibits canonical Wnt signaling	[37]
FZD7	Transmembrane Wnt receptor
		Ovarian	Promote cell migration and invasiveness	[42]
		Hepatocellular Carcinoma	Promote cell migration	[44]
		Colorectal	Promote cell migration	[45]
VANGL1	Transmembrane scaffold for Wnt/PCP signaling
		Glioblastoma	Promotes cell migration, scaffold for PCP negative regulator Nrdp1	[43]
		Colon	Promote cell migration	[46]
		Head and Neck Squamous Cell Carcinoma	Promote cell migration and metastasis	[47]
		Breast	Promote cell migration	[48]
VANGL2	Transmembrane scaffold for Wnt/PCP signaling
		Breast	Promotes cell migration and proliferation	[12]
PRICKLE1	Cytoplasmic scaffold for Wnt/PCP signaling
		Breast	Cell migration, proliferation and metastasis	[22], [50], [51]