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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Semin Cancer Biol. 2017 Sep 28;50:124–131. doi: 10.1016/j.semcancer.2017.09.009

Fig. 3. FOXO1 blocks neoplastic pathogenesis through multiple mechanisms in digestive malignancy.

Fig. 3

FOXO1 upregulates the levels of caspase and downregulates the levels of Bcl-2. Moreover, FOXO1 blocks cell cycle progression, meanwhile suppressing angiogenesis and enhancing apoptosis.