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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Hippocampus. 2018 Feb 12;28(4):251–268. doi: 10.1002/hipo.22832

Figure 2.

Figure 2

Select calcium signaling genes were normalized by MCS treatment in Ts65Dn mice at ~6 MO. A. Adcy1 is upregulated 1.21 fold (2N versus Ts) in Ts65Dn mice and downregulated in Ts+ mice relative to 2N and Ts levels by MCS treatment, while Adcy1 levels in Ts+ are not significantly different from 2N+ levels. B. Camk2a is upregulated 1.23 fold (2N versus Ts) in Ts65Dn mice and downregulated in Ts+ mice relative to 2N and Ts levels by MCS treatment, while Camk2a levels in Ts+ are not significantly different from 2N+ levels. C. Mapk13 is upregulated 1.28 fold (2N versus Ts) in Ts65Dn mice and downregulated in Ts+ mice (Ts+ versus Ts) to 2N levels by MCS. D. Npy1r is upregulated 1.23 fold (2N versus Ts) in Ts65Dn mice and downregulated in Ts+ mice (Ts+ versus Ts) to 2N levels by MCS. Significant differences due to MCS treatment in 2N mice were observed for Adcy1 and Camk2a. Key: *, p<0.01; **, p<0.005; ***, p<0.001. Upward arrowhead, significant upregulation; downward arrowhead, significant downregulation.