Fig. 2. Retrograde trajectory of (A) insulin sensitivity and (B) the insulinogenic index. Diabetes onset or the end of follow-up was set as time zero and each follow-up was traced towards the back. Modified and updated from Ohn et al., with permission from Elsevier [33]. ISI, composite (Matsuda) insulin sensitivity index (unitless); IGI, 1-hour insulinogenic index.