Table 2.
The incremental AUC of BG levels of GK rats in long-term administration test
| Week | Time period (min) | Blood glucose AUC (mM·min) |
||
|---|---|---|---|---|
| Control | SIF | ACR | ||
| 12 | 0–30 | 106.9 ± 17.8 | 79.5 ± 16.2 | 86.0 ± 11.3 |
| 30–60 | 195.7 ± 32.2 | 153.4 ± 24.1 | 153.7 ± 19.5 | |
| 60–120 | 316.3 ± 56.1 | 281.7 ± 33.6 | 261.0 ± 35.4 | |
| Total | 618.8 ± 93.9 | 514.2 ± 57.4 | 500.7 ± 53.5 | |
| 16 | 0–30 | 75.3 ± 23.6 | 51.3 ± 12.4 | 52.3 ± 13.3 |
| 30–60 | 142.7 ± 36.2 | 101.5 ± 29.7 | 99.7 ± 28.4* | |
| 60–120 | 236.3 ± 68.5 | 185.9 ± 41.3 | 163.3 ± 36.2 | |
| Total | 454.3 ± 82.7 | 338.8 ± 76.3 | 315.3 ± 61.5 | |
SIF (150 mg/kg BW) or ACR (3 mg/kg BW) were orally administered to the rats for 16 weeks. At week 12 (A) and 16 (B), animals were fasted and received maltose (2 g/kg BW), and an oral maltose tolerance test was carried out. The results are expressed as means ± SE of ten rats. *p<0.05, compared with control group.