Table 3.

Effect of SIF on blood biochemical parameters of GK rats in long-term administration test

Indexes	Control	SIF	ACR
Total protein (g/dl)	6.2 ± 0.3	6.1 ± 0.3	6.3 ± 0.2
Triglyceride (mM)	0.22 ± 0.03	0.27 ± 0.04	0.25 ± 0.03
Free fatty acid (mM)	0.73 ± 0.04	0.69 ± 0.06	0.62 ± 0.03
Cholesterol (mM)	2.7 ± 0.5	2.7 ± 0.6	2.9 ± 0.4
HDL-cholesterol (mM)	1.9 ± 0.3	1.9 ± 0.4	2.1 ± 0.4
LDL-C (mM)	0.81 ± 0.23	0.76 ± 0.14	0.86 ± 0.14
AST (U/L)	126 ± 19	134 ± 27	130 ± 26
ALT (U/L)	124 ± 25	128 ± 29	122 ± 23
Insulin (mU/L)	59.4 ± 18.3	64.4 ± 18.7	71.9 ± 20.1
GSP (mM)	1.54 ± 0.17	1.31 ± 0.19*	1.37 ± 0.16*
CRP (mg/L)	1.78 ± 0.23	1.20 ± 0.24*	1.39 ± 0.16*
TNF-α (µg/L)	81.5 ± 11.6	75.1 ± 8.6	70.3 ± 9.2*
IL-6 (ng/L)	383 ± 43.1	290 ± 25.4*	325 ± 28.5*
LPO (µM)	11.4 ± 2.0	9.7 ± 1.8*	8.1 ± 0.7*

SIF (150 mg/kg BW) or ACR (3 mg/kg BW) were orally administered to the rats for 16 weeks. At week 16, rats were anesthetized, sacrificed, and then blood samples were tested for the biochemical parameters. The results are expressed as means ± SE of ten rats. *p<0.05, compared with control group.