Table 2.
Questionnaire score changes regarding IBS symptoms†
| Placebo (n = 27) | BNR17 (n = 24) | |
|---|---|---|
| Q1. Abdominal pain | ||
| Week 0 → 4 → 8 | 4.7 → 4.5 → 2.9 | 3.6 → 1.8 → 1.2 |
| p value | 0.1142 | 0.0032 |
| Q2. Abdominal distension | ||
| Week 0 → 4 → 8 | 6.4 → 5.2 → 3.1 | 6.8 → 3.1 → 1.9 |
| p value | 0.1172 | <0.0001 |
| Q3. Satisfied defecation | ||
| Week 0 → 4 → 8 | 3.2 → 3.4 → 3.3 | 1.7 → 5.0 → 5.7 |
| p value | 0.8426 | 0.0008 |
| Q4. Disturbed daily life | ||
| Week 0 → 4 → 8 | 5.5 → 5.1 → 3.5 | 6.8 → 4.0 → 4.8 |
| p value | 0.1792 | 0.05 |
| Q5. Days of troublesome IBS symptoms within 10 days | ||
| Week 0 → 4 → 8 | 3.0 → 2.0 → 2.0 | 3.0 → 1.0 → 1.0 |
| p value | 0.3424 | 0.0051 |
| Q6. Mean defecation frequency | ||
| Week 0 → 4 → 8 | 2.0 → 2.0 → 1.5 | 2.5 → 2.5 → 1.5 |
| p value | 0.0172 | 0.0966 |
†Median, interquartile range (25%, 75%) in parentheses (all such values). Q1–Q4: Visual analogue scale, 0 (not at all)–10 (extremely), Q5: day, Q6: number of frequency. p value; Within-group comparisons using Wilcoxon signed rank test.