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. 2018 Mar 29;7:45. doi: 10.1038/s41426-018-0048-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative abscesses on day 2 after infection (4 isolates were randomly selected/lineage). Each mouse (one mouse/isolate) received 5 × 10⁷ CFUs on the right dorsum by intradermal injection. Control animals (n = 4) received only sterile PBS. b Abscess areas (=π (length × width)/2) on day 2 after infection. c, d Quantitative RT-PCR analysis of RNAIII and hla gene expression in randomly selected ST188 (10 isolates were randomly selected), CA-MRSA USA300(ST8), HO-MRSA ST398, and HA-MRSA ST239 (4 isolates were randomly selected/lineage), from cells grown to the late logarithmic growth phase (4 h). **, P < 0.01; ***, P < 0.001; NS, not significant (P ≥ 0.05)