Table 2.
MICs at time of isolation of all isolates included in this study and associated molecular resistance mechanism identified in this study
| Isolate ID | ANI | MICA | CAS | 5FC | POS | VOR | ITR | FLU | AmpB | Molecular resistance mechanism |
|---|---|---|---|---|---|---|---|---|---|---|
| 15B5 | 0.12 | 0.12 | 0.25 | 0.12 | 8 | 8 | 16 | 256 | 2 | Y132F in ERG11 |
| 15B6 | 0.06 | 0.06 | 0.06 | 0.06 | 0.015 | 0.25 | 0.06 | 256 | 1 | Y132F in ERG11 |
| 15B10 | 0.12 | 0.12 | 0.5 | 0.12 | 8 | 8 | 16 | 256 | 2 | Y132F in ERG11 |
| 16B12 | 0.12 | 0.12 | 0.5 | 0.25 | 8 | 8 | 16 | 256 | 2 | Y132F in ERG11 |
| 16B13 | 0.12 | 0.12 | 0.25 | 0.06 | 0.03 | 0.5 | 0.06 | 256 | 1 | Y132F in ERG11 |
| 16I29b | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Y132F in ERG11 |
| 16I29a | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Y132F in ERG11 |
| 16B18 | 0.25 | 0.25 | 1 | 0.06 | 0.12 | 2 | 0.12 | 256 | 1 | Y132F in ERG11 |
| 16B15a | 0.12 | 0.06 | 0.12 | 0.06 | 0.008 | 0.06 | 0.015 | 16 | 0.5 | Y132F in ERG11 |
| 16I17 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Y132F in ERG11 |
| 16B20 | 0.06 | 0.12 | 0.5 | 0.06 | 8 | 8 | 16 | 256 | 1 | Y132F in ERG11 |
| 16B16 | 0.12 | 0.12 | 0.25 | 0.06 | 0.03 | 0.25 | 0.03 | 256 | 1 | Y132F in ERG11 |
| 16B21 | 0.12 | 0.12 | 0.25 | 0.06 | 0.12 | 0.5 | 0.03 | 16 | 1 | Y132F in ERG11 |
| 16B22a | 0.12 | 0.12 | 0.25 | 0.06 | 0.008 | 0.25 | 0.03 | 128 | 0.5 | Y132F in ERG11 |
| 16B24a | 0.12 | 0.12 | 0.5 | 0.06 | 8 | 8 | 8 | 256 | 2 | Y132F in ERG11 |
| 16B22b | 0.12 | 0.12 | 0.25 | 0.06 | 4 | 8 | 2 | 256 | 1 | Y132F in ERG11 |
| 16B24b | 0.12 | 0.12 | 0.25 | 0.06 | 8 | 8 | 2 | 256 | 1 | Y132F in ERG11 |
| 16B25 | 0.12 | 0.12 | 0.25 | 0.06 | 0.03 | 0.12 | 0.03 | 64 | 1 | Y132F in ERG11 |
| 16I27a | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Y132F in ERG11 |
| 16B26 | 0.12 | 0.12 | 0.25 | 0.06 | 8 | 8 | 16 | 256 | 1 | Y132F in ERG11 |
| 16B27b | 0.12 | 0.12 | 1 | 0.12 | 8 | 8 | 16 | 256 | 0.5 | Y132F in ERG11 |
| 16I30 | 0.25 | 0.12 | 0.5 | 0.12 | 8 | 8 | 16 | 256 | 2 | Y132F in ERG11 |
| 16B15b | 8 | 8 | 8 | 64 | 0.015 | 0.25 | 0.03 | 8 | 1 |
S652Y in FKS1; F211I in FUR1; Y132F in ERG11 |
| 16B30 | 0.12 | 0.06 | 0.12 | 0.06 | 0.15 | 0.5 | 0.06 | 128 | 1 | Y132F in ERG11 |
| 16B31 | 0.12 | 0.06 | 0.12 | 0.06 | 0.03 | 0.5 | 0.06 | 256 | 1 | Y132F in ERG11 |
| 16I33 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.03 | 128 | 0.5 | Y132F in ERG11 |
| 16I34 | 0.06 | 0.06 | 0.06 | 0.06 | 0.008 | 0.25 | 0.03 | 256 | 0.5 | Y132F in ERG11 |
MICs for FLU, ITR, VOR, POS, CAS, MICA AmpB, and ANI were above these tentative epidemiological cutoffs (ECOFF)3 and C. albicans ECOFF for 5FC27, 60 and are therefore resistant (in bold font)
ANI anidulafungin, MICA micafungin, CAScaspofungin, 5FC 5-fluorocytosine, POS posaconazole, VOR voriconazole, ITR itraconazole, FLU fluconazole, AmpB amphotericin B, N/A no MICs carried out