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. 2018 Mar 28;6:8. doi: 10.1038/s41413-018-0011-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PU.1 is necessary for looping a conserved enhancer at the Nfatc1 locus. a Depiction of murine PU.1 MP and OC ChIP-Seq peaks and murine BMDM H3K27Ac active enhancer mark ChIP-Seq peaks ± 25 kb from the TSS of Nfatc1 (top). BglII sites used for 3C (below top trace). Trace of PU.1 and H3K27Ac ChIP-Seq peaks from human PBMCs ± 25 kb from the TSS of NFATc1 (bottom). b 3C assay from murine MPs and OCs (n = 2). BglII sites on the x-axis correspond to the indicated site ligating with the common forward site (C1) at the Nfatc1 promoter. c 3C assay results from murine WT OCs and Pu.1 KO OCs (n = 2). d 3C assay from murine WT MPs and Pu.1 KO MPs (n = 2).