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. 2018 Jan 18;37(13):1759–1774. doi: 10.1038/s41388-017-0118-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 8 — Low NDRG2 expression and an NDRG2_low/Skp2_high gene expression signature correlate with poor patient outcome. a Immunohistochemistry staining of NDRG2 and Skp2 in human adjacent normal and cancerous colon tissues from CRC patients. b Negative correlation between NDRG2 and Skp2 expression levels with linear regression and Pearson’s correlation significance (P < 0.0001, ANOVA test). c Negative correlation between NDRG2 and Skp2 mRNA expression patterns in TCGA cbioportal data set with linear regression and Pearson’s correlation significance (P < 0.001, ANOVA test). d, e Skp2 expression by immunohistochemistry staining in human tissues at different stage d or differentiation status e. f, g Kaplan–Meier plots indicate the clinical outcomes for Skp2 expression f and NDRG2_low/Skp2_high expression signature g by immunohistochemistry staining in CRCs. n indicates the number of patient samples evaluated in each analysis. P-values were calculated using the Mantel–Cox log-rank test. h The proposed mechanism of NDRG2 action in regulation of CRC differentiation