Fig. 8.

Inhibition of mPTP prevents breast cancer cell death caused by the loss of Cdk5. MDA MB-231 and MCF-7 breast cancer cells depleted of Cdk5 were treated with CsA (1 µM), SFA (2 µM), Mito-Tempo (5 µM), or Mdivi-1 (10 µM) 4 h post-transfection. Surviving fractions of Cdk5-depleted cells were normalized with surviving fractions of cells transfected with control siRNA. Data represent means ± SD from four independent experiments