Table 4. Concentrations and activities of selected haemostatic parameters depending on clinicopathological determinants in all patients from the study group (n=85).
| Coagulation assays | TF activity | TF concentration | TF/TFPI activity ratio | TFPI activity | TFPI concentration | TF/TFPI concentration ratio | t-PA concentration | PAI-1 concentration |
|---|---|---|---|---|---|---|---|---|
| P-values | P-values | P-values | P-values | P-values | P-values | P-values | P-values | |
| Age <55 years | 14.99/11.62/25.06 | 571.26/472.58/747.90 | 11.02/8.28/26.25 | 1.34/1.06/1.0 | 40.68/31.96/49.64 | 14.17/8.89/20.92 | 4.61/3.92/6.06 | 38.52/27.73/57.86 |
| Age ≥55 years | 13.16/11.03/26.92 | 500.39/387.90/602.66 | 10.43/7.37/24.13 | 1.30/1.12/1.48 | 48.24/41.00/64.24 | 10.02/8.46/11.75 | 5.38/4.20/6.66 | 37.19/28.10/44.46 |
| P=0.7299 | P=0.1320 | P=0.7038 | P=0.9800 | P=0.0029 | P=0.0045 | P=0.3443 | P=0.2377 | |
| Localization of tumour: left breast | 14.69/10.41/30.18 | 564.06/420.25/702.60 | 9.73/7.12/30.49 | 1.37/1.10/1.58 | 46.68/38.54/62.34 | 10.62/8.34/17.78 | 5.41/4.23/6.78 | 43.24/33.83/53.79 |
| Localization of tumour: right breast | 13.88/11.86/25.19 | 491.16/392.64/654.26 | 11.02/8.77/22.43 | 1.20/1.10/1.46 | 43.00/34.34/55.00 | 10.77/9.36/16.11 | 5.11/3.44/6.25 | 35.61/24.18/42.91 |
| P=0.9147 | P=0.5010 | P=0.8424 | P=0.2043 | P=0.2098 | P=0.6500 | P=0.4354 | P=0.0291 | |
| Ki67 ≤14 % | 13.88/11.03/25.56 | 520.76/387.68/726.12 | 11.02/7.49/26.25 | 1.28/0.98/1.48 | 44.80/38.00/60.16 | 10.37/8.77/15.07 | 5.10/3.45/7.12 | 37.19/27.30/44.61 |
| Ki67 ≥15% | 14.99/11.17/31.56 | 562.47/439.56/686.50 | 10.56/7.08/25.81 | 1.38/1.10/1.54 | 42.36/32.96/61.88 | 11.38/8.47/20.92 | 5.30/4.23/6.70 | 39.50/28.10/53.01 |
| P=0.9319 | P=0.5235 | P=0.5875 | P=0.1438 | P=0.6731 | P=0.4333 | P=0.5669 | P=0.3103 | |
| Clinical classification TNM - pT1 (a, b, c) | 15.09/11.59/25.56 | 530.35/400.86/718.70 | 11.40/8.12/29.81 | 1.29/0.97/1.58 | 44.74/36.28/61.64 | 10.97/8.47/17.58 | 4.59/3.44/6.25 | 38.65/28.10/54.56 |
| Clinical classification TNM - pT2 | 13.04/9.58/25.26 | 540.65/396.79/652.06 | 10.17/7.22/20.38 | 1.33/1.20/1.45 | 44.32/38.96/57.96 | 10.67/9.11/14.82 | 5.94/4.69/7.25 | 36.85/26.14/43.25 |
| P=0.3463 | P=0.8286 | P=0.2534 | P=0.6887 | P=0.8753 | P=0.9525 | P=0.0325 | P=0.1499 | |
| Histological type IDC | 14.59/10.82/25.38 | 540.65/390.27/682.33 | 11.40/7.62/27.12 | 1.31/1.08/1.48 | 44.36/37.38/60.26 | 10.68/8.72/15.97 | 5.19/3.97/6.68 | 38.54/30.29/48.86 |
| Histological type ILC | 12.31/11.65/13.32 | 539.93/444.32/728.94 | 8.73/7.37/10.26 | 1.56/1.28/1.60 | 44.48/35.60/53.92 | 11.62/9.77/20.18 | 5.26/4.14/7.16 | 28.10/22.66/35.12 |
| P=0.4610 | P=0.5055 | P=0.1606 | P=0.0248 | P=0.7693 | P=0.5521 | P=0.7154 | P=0.0275 | |
| Luminal-A type of BrCa, n=58 | 13.79/10.82/25.19 | 530.85/400.90/698.45 | 10.79/7.39/24.77 | 1.27/1.10/1.49 | 46.42/36.70/59.88 | 10.76/8.47/16.44 | 4.82/3.65/6.50 | 36.36/27.58/45.23 |
| Other molecular types of BrCa, n=27 | 19.62/11.86/38.98 | 563.96/439.56/718.70 | 16.21/8.28/30.99 | 1.40/1.22/1.54 | 41.00/34.36/61.64 | 11.97/8.89/19.52 | 5.71/4.34/6.70 | 40.44/36.46/49.60 |
| P=0.1264 | P=0.6939 | P=0.4524 | P=0.1422 | P=0.3904 | P=0.4047 | P=0.4998 | P=0.1568 |
Data are expressed as median (Me) and the IQR (lower quartile (Q1, upper quartile (Q3)); TNM classification of malignant tumours. Abbreviations: IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma.
Significant differences are denoted by bold P-values.